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Lysosomes also serve as signaling hubs to monitor the intracellular levels of nutrients and energy by acting as platforms for the assembly of multiple signaling pathways, such as mammalian target of rapamycin complex 1 (mTORC1) and adenosine 5-monophosphate (AMP)-activated protein kinase (AMPK)

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Despite all these concerns about the conduct of the study, the results of TACT were fairly modest, limited to a reduction in the need for future stents, and seemed to be most pronounced only in diabetics

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