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Phase Titration Dose 75 mg Frequency 1-3x weekly Notes Increase by ~25 mg if assessment phase is well tolerated
GLP-1RAs such as CNTO3649 and exendin-4 reduced hepatic steatosis and lowered hepatic triglyceride, cholesterol, and phospholipid contents in HFD-fed APOE*3-Leiden transgenic mice [27]
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This comprehensive guide has outlined the essential considerations for implementing these protocols in research settings, from basic dosage guidelines to advanced safety monitoring requirements
