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Description
In the context of MTHFR variants, providing the body with methylfolate will help counter its own, reduced production of methylfolate

Phase Split option Daily dose 50 mg morning + 50 mg midday Notes Some sources prefer split AM dosing because the plasma half-life is short (about 4 to 7 hours in rodent PK)

The 1000 mcg dose is seen as effective

In a pilot study during 1 month of four patients with Crohns disease the mean serum cobalamin concentration increased significantly after weekly administration of 1500 g of the same formulation
