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A crucial mechanistic insight is that Beclin1 dynamically oscillates between inactive homodimers and active heterodimers formed with Vps34

Previous cancer research on steroidogenesis has focused primarily on classical steroidogenic tissues (e.g., ovarian and testicular cancer) and a limited number of other tissues such as brain, gut, heart, prostate and skin where steroidogenesis was shown to occur and impact both local and systemic immunity

Sideroxylon (Callistemon lanceolatus) suppressed cell proliferation and increased apoptosis in ovarian cancer cells accompanied by mitochondrial dysfunction, the generation of reactive oxygen species, and an increase of lipid peroxidation

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