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& Desnick, R

These pathways include the cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis 1,4 , the ferroptosis suppressor protein 1 (FSP1)/coenzyme Q 10 (CoQ 10 ) axis on the plasma membrane 5,6 , the guanosine triphosphate cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4)/dihydrofolate reductase (DHFR) axis 7,8 , and the mitochondrial dihydroorotate dehydrogenase (DHODH)/CoQ system 9

Degradation of heparan sulfate proteoglycans enhances oxidized-LDL-mediated autophagy and apoptosis in human endothelial cells

In summary, the combination of two different tags flanking the N- and the C-terminal and the capability to cleave off one of the tags, guaranties the recovery of a highly purified and full-length protein of interest