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Specifically, genetic activation of Nrf2 in Kelch-like ECH-associated protein 1 (Keap1)-knockdown mice significantly increased hepatic ALT1 and renal ALT2 mRNA levels, whereas genetic deletion of Nrf2 ( Nrf2 -knockout) reduced hepatic ALT2 and renal ALT1 mRNA levels [39]

[141], used an in vitro bloodbrain barrier (BBB) endothelial cell model of CoQ 10 deficiency, and identified lipoprotein-associated uptake and efflux mechanisms regulating CoQ 10 distribution across the BBB (Figure 6b)

LncRNA DLX6-AS1 promotes microglial inflammatory response in Parkinsons disease by regulating the miR-223-3p/NRP1 axis

This review aimed to elucidate the dynamic changes and functions of the HIF and NRF2 signaling pathways, particularly in response to hypoxia and oxidative stress conditions, with a specific emphasis on their implications within the tumor milieu