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Peripheral nerves develop insulin resistance, rendering insulin receptors on SCs and axons unresponsive

Figure 1 2.1 IR and diabetes mellitus According to the 10th edition of the IDF Diabetes Atlas, 536.6 million people worldwide have diabetes, which means that more than 10.5% of the worlds adult population has the disease, and this number continues to grow, predicted to rise to 12.2% (783.2 million people) by 2045 (13)

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Glucokinase stably associates with nNOS allowing the S-nitrosylation reaction to proceed