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Pitts and Okhuysen, 1984

There are anecdotal reports from patients and providers about improved energy and mood by adding vitamin B12 to GLP-1 treatment

Kang Y, Ren P, Shen X, Kuang X, Yang X, Liu H et al (2023) A newly synbiotic combination alleviates obesity by modulating the gut microbiotafat axis and inhibiting the hepatic TLR4/NF-B signaling pathway
This might need to be supplemented with medication
