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Conversely, mast cells may also communicate with neurons via transgranulation, whereby mast cell granules can be inserted into adjacent neurons that alters neuronal responsiveness to its microenvironment (Wilhelm et al., 2005) (see Figure 3)
This likely relates to the fact that ascorbate is avidly retained by the CNS during ascorbate deficiency [175]
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The SMT-conjugate exposure is mainly due to the cysteine metabolite, to which IGSH and ICGS were rapidly converted in vivo
