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Nevertheless, there have been few investigations into the use of CRISPR-Cas9 in folate biofortification, so further research is required to assess the potential benefits and risks associated with this application

Available human studies are characterized by relatively small sample sizes, heterogeneity in dosing regimens, and short intervention durations, which restrict the ability to draw firm conclusions regarding efficacy and optimal therapeutic windows

This was intriguing, as drug resistance was traditionally associated with increased GSH levels [25, 26]

Search strategy We conducted searches in Medline, Extended Medline (1950 to 22 July 2020) using the following search words (Vitamin B12 or Cobalamin or Methylcobalamin or Cyanocobalamin) and (Autism, Autistic spectrum disorder or attention deficit hyperactivity disorder or ASD or ADHD)