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Description
Evidence from human kidney disease In humans, tubular cell death was the best histopathological correlate of renal dysfunction in the so-called acute tubular necrosis form of AKI.81 Acute tubular necrosis (a term coined in the 19th century an unrelated to current concepts of cell death modalities) is the most common form of AKI

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Specifically, sympathetic overactivation primarily acts through the -adrenergic receptorG s cAMPPKA/CaMKII pathway