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Keywords: Endometrial cancer, mismatch repair-deficiency, microsatellite instability, checkpoint inhibitors, MMR-D mechanism, Lynch Syndrome, genetic testing Precis: Molecular subtyping utilizing comprehensive assessments of mismatch repair deficiency (MMR-D) and microsatellite instability (MSI-H) is of paramount importance in endometrial cancer (EC) and drives recommendations for genetic testing given the association with Lynch Syndrome

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