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Bischof K, Moitzi D, Stoop R, et al

doi: 10.1186/s12967-025-06315-7

Address methylation bottlenecks Distinguish low SAM from high SAH Review homocysteine, adenosine-related metabolism and kidney function Support transsulfuration and glutathione when appropriate Avoid automatic folate or methyl-donor treatment 6

Creatine is vital for mitochondrial energy buffering it stores and transfers phosphate groups that recycle ATP, the cells main energy currency
