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Synthetic antioxidants, such as edaravone, amifostine, and N-acetylcysteine, demonstrate targeted protection against oxidative stress induced by cancer therapies, and enhanced bioavailability [233]

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For comparison with leaching of molecular dye, similar PLGA nanoparticles were loaded with Nile red, a popular dye used for labeling PLGA and other polymers 50 , and found to leach 32.2 6.7% of initial load after only 6 hrs

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