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a , Liver samples were collected from mice treated with AAV8-GFP (n=8) or AAV8-AGXT (n=6), stained for F4/80 (red) and DAPI (blue) to visualize nuclei, analysed for ( b ) F4/80+ cells and expressed as fold change from AAV8-GFP

Therefore, lipid metabolism is an important regulator of TME and ferroptosis of tumor cells (201)

Furthermore, it was demonstrated that ROS are able to block OL maturation in vitro by arresting them in the progenitor phase by decreasing the expression of genes involved in OL differentiation and increasing the expression of genes known to inhibit differentiation [25]