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Cytokines and chemokines Increased production and release of cytokines [e.g., interleukins (IL): IL-1, IL-6, IL-8, tumor necrosis factor (TNF), and interferon (IFN-)] and chemokines (e.g., CCL2, and CXCL12, CCL11, CCL3, and CCL4) and decreased expression of anti-inflammatory cytokines (IL-10 and IL-4) are observed after the administration of several chemotherapeutics including paclitaxel, cisplatin and vincristine

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