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Nat Rev Gastroenterol Hepatol 23 , 331354 (2026)

First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors

The compound's unique mechanism of action simultaneously preserving NAD+ availability and methylation capacity through selective NNMT inhibition offers researchers a powerful approach to investigating metabolic flexibility and cellular adaptation

For reproductive applications, this strategy is often well suited to mechanistic stratification because it yields stable axes that can be interpreted in terms of coherent programs, including progesterone-response attenuation, decidualisation trajectory deficits, inflammatory activation, or metabolic stress, while supporting subsequent assay compression into targeted panels [450]