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Response: As most recently discussed in the CY 2023 HH PPS final rule (87 FR 66848), the HH PPS market basket updates are set prospectively, which means that the market basket update relies on a mix of both historical data for part of the period for which the update is calculated and forecasted data for the remainder

Shiloach J, Kaufman J, Guillard AS, Fass R

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However, despite the encouraging evidence, gaps in our knowledge remain to be filled in order to fully understand the mechanisms connecting NNMT with MetS-related disorders and to develop clinical agents against NNMT