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10.1038/nprot.2010.123 58 Van Der SchouwY

A mouse strain deficient in the common chain, CD131, shared by the IL-3, GM-CSF, and IL-5 receptors have reduced lung eosinophilia in asthma models,12 whereas mice deficient in both CCL11 and IL-5 have even greater reduction in tissue eosinophils in asthma models.13 The highly eosinophil-specific expression of eosinophil peroxidase (EPO) has been exploited for the development of an eosinophil-deficient mouse (so-called PHIL mice, eosinoPHIL minus eosino mice) in which expression of a toxin is molecularly linked to EPO expression, resulting in eosinophil death before they leave the bone marrow.14 These eosinophil-less mice have subsequently been employed in various disease models, including asthma

Kim, Mison Chun, Jaeyong Shin BMC Medicine.2025;[Epub] CrossRef Global, regional, and national burden of leukemia: Epidemiological trends analysis from 1990 to 2021 Chengjun Hu, Weifeng Chen, Ping Zhang, Tongping Shen, Maozhong Xu, Victoria Pando-Robles PLOS One.2025

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