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La disminucin de los niveles de TNF- e IL-6 indica que la inhibicin de NNMT no solo modula el metabolismo, sino que tambin mejora el microambiente inflamatorio, un componente clave en el desarrollo de enfermedades metablicas y la resistencia a la insulina

The medication is primarily approved for type 2 diabetes but is commonly prescribed off-label for long-term weight management, while Phentermine is FDA-approved specifically for short-term weight loss and is typically used for only a few weeks

However, the further clinical development of pramlintide/metreleptin combination therapy has been discontinued by the manufacturing companies because of safety concerns [249](Table 3 )

Clinical trials have shown positive results regarding the efficacy of AOD-9604 for weight loss in humans, with one study reporting an average loss of 2.6 kg over 12 weeks, compared to 0.8 kg in the placebo group