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Ahmad M, Wolberg A, Kahwaji C

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Alteration of several metabolic enzymes and pathways that affect KG abundance and KGDD activity have been reported in cancer, such as mutations of the genes encoding isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2), changes in glutaminolysis that deplete KG, and alterations in fumarate hydratase and succinate dehydrogenase that inhibit KGDD activity 11

Unamuno X, Gmez-Ambrosi J, Rodrguez A, Becerril S, Frhbeck G, Cataln V (2018) Adipokine dysregulation and adipose tissue inflammation in human obesity