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In this five-year update of the ECHELON-2 trial, the frontline treatment of patients with PTCL using A + CHP continues to provide clinically meaningful improvements in PFS and OS compared to CHOP, with a manageable safety profile, including the continued resolution or improvement of peripheral neuropathy [226]
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& Kincade, P
Furthermore, Kaplan-Meier survival analysis indicated that patients with high OTUB1 expression had significantly shorter overall survival (OS), suggesting that this molecule can serve as an independent predictor of poor prognosis in gliomas
