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However, due to the difference in the natural history of the two forms of chronic liver failure and ALF, NAC has been less studied in patients with ALF

Importantly, as the nervous system ages, there is also a rarefaction of the microvasculature in different regions of the brain, as well as alterations in the structure of the remaining vessels, which have been causally linked to cognitive dysfunction in older humans[341, 342]

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In the second study, only patients with advanced CRC who were not previously treated with chemotherapy were included [89]