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Results show that NAC significantly reduces oxidative stress in NPC disease but has no effect on autophagic dysfunction-related cholesterol accumulation, thus failing in clinical trials ( 2.1 SQSTM1 SQSTM1 (sequestosome1, also called p62) is an autophagy adapter protein that participates in the degradation of protein aggregates and cytoplasmic bodies (Lin et al., 2013)

The predominant trigger for eNOS phosphorylation is fluid shear stress in the vasculature

16 Upon reaching its target tissues, Cu catalyzes reactions in a wide range of physiological processes, including mitochondrial energy production, tyrosine and neurotransmitter metabolism, redox homeostasis, and extracellular matrix remodeling
