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Proteins were injected intraperitoneally at the time of inoculation with 20 mg kg 1 cetuximab (3.33 nmol per animal), 2.2 mg kg 1 Albu-LiTE construct (500 pmol per animal) or 1.0 mg kg 1 LiTE (500 pmol per animal)

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For either compound to move from no toxicity demonstrated to safety established for a defined use, the following would ordinarily be required and none of it is presently complete in the public record for these substances as sold: GLP-compliant repeated-dose toxicity of adequate duration typically up to chronic (6- to 12-month) studies in a rodent and a non-rodent species, with full clinical pathology and histopathology, to detect cumulative organ effects

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