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It could potentially interact with medications

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Mutations in ATP5F1E , ATPAF2 , ATP5PO , and TMEM70 , all encoded by nDNA, are also implicated in seizure disorders (108, 118, 119)

While there are no direct, large-scale human clinical trials on BPC 157 specifically for sciatica, we can connect the dots based on its known mechanisms of action and how they relate to the pathology of sciatica