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Hepatic and gastrointestinal effects Clinical manifestations of raised copper levels in the liver due to copper sulfate poisoning comprise a wide range of signs and symptoms, including delicate and asymptomatic morphological changes in the hepatic tissue, self-limiting hepatitis-like disease to severe hepatitis, recurrent jaundice, if associated with hemolysis of red blood cells, cirrhosis, and even acute liver failure [23]

Prompt treatment is necessary for patients with obvious symptom or tendency of organ dysfunction [189]

Aldehyde dehydrogenase 1 is associated with recurrence-free survival but not stem cell-like properties in hepatocellular carcinoma