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In a mouse model of hepatocellular carcinoma, regulatory T cells (Tregs) with high IGF-1R expression presented increased PI3K/AKT/mTOR signaling and were able to produce more ATP, lactate and ROS, which contribute to enhanced immunosuppressive effects (72)
Cold Spring Harbor Perspect Biol (2013) 5:a008722
Relationship between cortical iron and tau aggregation in Alzheimer's disease
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