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Individuals with cancer history may wish to avoid HGF-modulating compounds out of caution

Active Ingredients: Each mL OF sterile aqueous solution contains: Cyanocobalamin (B12) 5,000 mcg Sodium chloride 0.22% w/v Ammonium sulfate 00.1% w/v Citric acid 0.01% w/v Sodium citrate 0.008% w/v Benzyl alcohol (preservative) 1.0% v/v Indications: For use as an aid in the management of vitamin B12 deficiencies in horses, dogs and cats

This effect was associated with upregulation of hydroxyindole-O-methyltransferase (HIOMT), a key enzyme in melatonin biosynthesis (Khavinson & Anisimov, Neuroendocrinology Letters, 2000)

B12 is water-soluble, so excess is excreted in urine