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Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase
Tobacco smoke contains a complex mixture of potentially toxic chemicals that directly generate ROS

It's a starting point inherited from preclinical models that prioritized observable outcomes over dose efficiency

In Arabidopsis, the TFs WRKY46, WRKY54, and WRKY70 are involved in brassinosteroid-regulated growth and drought response in Arabidopsis (Lozano-Sotomayor et al., 2016)