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Biological timing and clock gene expression play important roles in the cerebrovascular and cardiovascular systems

Previous studies have shown that modulation of vagus nerve (VN) activity, a key communication pathway between the brain and the gut, may produce therapeutic effects in PD and influence its disease course by regulating the gut microbiota, brain plasticity, neuroimmune, and neuroendocrine systems, while the nerve itself also plays a complex role that can contribute to pathological processes like disease propagation

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Sex-dependent co-occurrence of hypoxia and beta-amyloid plaques in hippocampus and entorhinal cortex is reversed by long-term treatment with ubiquinol and ascorbic acid in the 3xTg-AD mouse model of Alzheimers disease