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The two-layer membrane divides mitochondria into multiple cavities, which is known as mitochondrial compartmentalized structure. The mitochondrial structure mainly includes four distinct regions, including mitochondrial outer membrane (Outer Mitochondrial MembraneOMM), mitochondrial inner membrane (Inner Mitochondrial MembraneIMM), mitochondrial matrix, and intermembrane space (Kramer and Bressan, 2018)

doi: 10.1021/np300824h 293 WuYBZhengCJQinLPSunLNHanTJiaoLet al

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Paradigm shift redefining molecular, metabolic and structural events in Alzheimers disease involves a proposed contribution by transition metals