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FEBS J 285:13261345 Tohme S, Yazdani HO, Liu Y, Loughran P, van der Windt DJ, Huang H, Simmons RL, Shiva S, Tai S, Tsung A (2017) Hypoxia mediates mitochondrial biogenesis in hepatocellular carcinoma to promote tumor growth through HMGB1 and TLR9 interaction

Integrating these datasets with machine learning and systems biology approaches will enable the construction of predictive models that classify patients according to metabolic vulnerabilities, thereby guiding rational trial design and therapeutic personalization

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Kim JI, Kim JW, Park S, Hong SB, Lee DS, Paek SH, et al