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This gap is due to issues in designing nanoparticles, size and shape control, stability over a long period, and immunogenicity of the nanoparticles
MK-2461, a novel multitargeted Kinase inhibitor, preferentially inhibits the activated c-met receptor

In addition, HP--CD loaded with LNG increased the drug loading capacity to 3380.56 g/mL, exhibiting a similar pharmacokinetic curvature as oral LNG suspensions (Fig

Additional TME factors, including IL-6 and PD-1AhR signaling, exacerbate mtROS accumulation and promote metabolic exhaustion, ultimately leading to NK cell apoptosis and loss of intrahepatic tumor surveillance [11, 172]
