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Athletes who participate in sports requiring repetitive running or jumping are most likely to suffer attritional patellar tendon injury

Attention is paid primarily to the attenuation of various intracellular signals in target cells, e.g., rearrangement and disruption of the internalization of the allergen-bridged high-affinity IgE receptor (FcRI), transinhibition or internalization of the FcRI receptor with engagement of the low-affinity inhibitory receptor for the Fc region of immunoglobulin gamma (FcRIIb), synthesis of blocking drug-specific immunoglobulins G4 (IgG4), alteration of signaling pathways in mast cells and/or basophils, and reduced calcium ion (Ca2+) influx into cells (Figure 6) [109,112,113,114]

The protective variant at rs2304256 was shown to decrease STAT1 phosphorylation in B lymphoblastoid cell lines when stimulated with IFN (67)

Guerrero et al