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Subunits from each of the four septin subgroups assemble into hetero-oligomeric complexes in a specific order, including hexamers (SEPT2SEPT6SEPT7SEPT7SEPT6SEPT2) and octamers (SEPT2SEPT6SEPT7SEPT9SEPT9SEPT7SEPT6SEPT2), with alternating G-interface (consisting of the GTP-binding domain) and NC-interface (comprising the amino- and carboxy-terminal regions) along the linear hetero-oligomeric complex 8,11

TABLE 3-5 Substances Most Frequently Involved in Human Poisoning Exposures TABLE 3-6 Poisons Associated with the Largest Number of Human Fatalities Sedatives/hypnotics/antipsychotics Acetaminophen Opioids Antidepressants Cardiovascular drugs Stimulants and street drugs Alcohols Bronstein AC, Spyker DA, Cantilena LR, et al

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Clinical Science and Molecular Medicine 1977;53:4537