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Taken together, these recent findings have uncovered a mechanistic relationship between epigenetic dysregulation and several signaling pathwaysmTOR, WNT, Notch, and BDNF-TrkBin ASD development to pave the way for novel therapeutic developments to alleviate ASD symptoms (Figure 3)

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Reduced concentrations of inflammatory cytokines, including IL-2 and IL-1, were also reported

Results Analysis of NAD and glutathione forms from the whole blood First, to enable analysis NAD + , NADH, NADP + , NADPH, GSH and GSSG from large human cohorts, we developed a quantitative measurement of these six metabolites from a single blood sample (Fig