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Safety Producer organisms such as mushrooms are well known to make many secondary metabolites, some of which can be highly toxic (354356) and by various mechanisms (357)

(2004) confirmed the safety and tolerability of repeated doses of aerosolized AAV2 containing CFTR complementary DNA (cDNA)
The protective role of endogenous melatonin in carrageenan-induced pleurisy in the rat
Urol 2012, 819202 (2012)