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Particularly insightful mechanistic evidence comes from a medaka fish NAFLD model, where metabolomic analysis revealed that L-carnitine not only reduced hepatic lipid deposition but also significantly elevated hepatic -oxidation end products (acetyl-CoA and ATP) while upregulating antioxidant enzyme superoxide dismutase 2 (SOD2) (35)

Holmes recalled that Bowman was a good father until his younger half-brother David was born, at which point Bowman reportedly lost interest in his stepchildren and began neglecting them

A more recent study confirmed that Cer 16:0 with the usual sphingoid base sphingosine (d18:1) is the most abundant ceramide in human WAT, indicating its vital role in adipose tissue metabolism and suggesting the association between ceramide profiles and the development of obesity in humans 2,101