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Description
Using gene editing tools such as CRISPR/Cas9, researchers can knock out key genes like PHGDH to directly regulate serine synthesis at the genetic level
First, for participants enrolled early during the study (mainly participants in cohorts 1 and 2), by our original study protocol, MAIA testing was conducted every 3 months rather than every 4 weeks, and thus macular sensitivity measurements were not available at week 4, 8, and 16 visits
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NPs have also targeted other microglia-specific receptors such as scavenger receptors, receptors for advanced glycation end products (RAGE), and cluster of differentiation (CD) receptors (82), improving uptake in vitro and calling for more such investigations in vivo
