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L., Gongora, R., Feghali-Bostwick, C., Lasky, J

When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted

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When it does so beneath the jawline, it sags visibly enough to look like a second chin
