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Levodopa-Induced Dyskinesia in Parkinsons Disease: Pathogenesis and Emerging Treatment Strategies

The effective blood-brain barrier mechanism impeding the transport of monoamines has been attributed to both the presence of tight junctions cementing adjacent endothelial cells of the cerebral capillary walls, along with high concentrations of dopa decarboxylase and monoamine oxidase (MAO) in the cerebral capillary endothelium (Bertler et al, 1966

A better understanding of how its synthesis is regulated and dysregulated in disease states may lead to improvement in the treatment of these disorders

Post-birth vulnerability continues: 64% of infants receive acetaminophen after vaccinationpotentially the "last straw" for already-vulnerable systems with immature detoxification capacity