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Regular cold therapy can reasonably continue as part of a sustainable wellness routine

The Phase 2/3 LIFT-AD trial (NCT04488419), evaluating once-daily subcutaneous fosgonimeton 40 mg versus placebo in 312 participants with mild-to-moderate Alzheimers disease over 26 weeks, failed its primary endpoint (Global Statistical Test composite of ADAS-Cog11 and ADCS-ADL23) and its key secondary endpoints when results were announced in September 2024

These indicate either excessive dosing or sensitivity to the peptide

While some of these sources provide legitimate products, the lack of regulatory oversight means that quality cannot be guaranteed