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The inhibition of CAT activity is suggestive of enhanced synthesis of O2- during the ingestion of alcohol and PUFA since O2- is a powerful inhibitor of catalase (46)
doi: 10.1161/JAHA.119.013572
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This prevents the hydroxylation of HIF-1, thereby blocking its recognition and subsequent degradation by the VHL-mediated proteasomal system [96, 97]
