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A principal preocupao terica sua ao pr-angiognica (via VEGF), que requer cautela em pacientes com histrico oncolgico
doi: 10.1111/1541-4337.12701, 15

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A causal role for portal hypertension in the pathogenesis or further progression of the barrier defect in chronic liver disease is suggested by an improvement of intestinal permeability and LBP levels with non-selective beta-blockers and transjugular intrahepatic portosystemic shunting (TIPS) (156, 157)
