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Description
A meta-analysis of cytokines in Alzheimers disease
Bundschuh, D
Some evidence suggests that in AD, dysregulation of tight junction proteins, increased matrix metalloproteinase signaling, and degeneration and loss of pericytes may all contribute to BBB leakage, leading to the accumulation of numerous blood-derived neurotoxic proteins in the brain, causing neuroinflammation and oxidative stress
Sometimes the actual pigment of the skin can be darkened
