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bioavailability determines whether it actually works once its there
The multiplicity of DGCs, PDEs and c-di-GMP-binding effectors in many bacterial species allows a plethora of signals to be integrated
Once you reach a maintenance dose, there's no flexibility to increase without switching to a new product or waiting for the next dose tier
15 A detailed review of the neurophysiology of spinal spasticity has been provided by Ashby and McCrea
