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The rats were administered once-daily s.c

A Brief History of GH Secretagogues The GH secretagogue story begins in the 1970s when Cyril Bowers discovered that small synthetic peptides based on enkephalin could release GH from pituitary cells without acting through opioid receptors

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Previous studies have also demonstrated that CGRP is secreted from EM lesions, leading to the release of Ca + 2 and increased inflammation [29, 30] (Fig