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In this regard, a major hydrogen peroxide detoxifying system in plant cells under abiotic stressors is the ascorbate-glutathione cycle, in which ascorbate peroxidase (APX) isoenzymes play a key role in catalyzing the conversion of H 2 O 2 into H 2 O, using ascorbate as a specific electron donor [51,52], particularly in the chloroplast (Figure 3)

Building on this trial, the global phase III MIRASOL trial randomized patients with FR-positive, platinum-resistant disease to MIRV versus investigators choice chemotherapyshowing significantly improved PFS, OS, and objective response rate with the ADC [14]

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