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Moreover, it opsonizes bacteria with an increased uptake by human macrophages and neutrophils, it enhances NO production in neutrophils through the upregulation of eNOS, and it was discussed that the monomer initiates calcium mobilization and the activation of calmodulin and PI3K to result in NO creation in neutrophils [82]

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In these models, prophylactic administration of ALC has proven to be effective in preventing the development of neuropathic pain

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